ERIC Number: EJ1055452
Record Type: Journal
Publication Date: 2015-Apr
Abstractor: As Provided
Reference Count: 117
Autism Biomarkers: Challenges, Pitfalls and Possibilities
Anderson, George M.
Journal of Autism and Developmental Disorders, v45 n4 p1103-1113 Apr 2015
Network perspectives, in their emphasis on components and their interactions, might afford the best approach to the complexities of the ASD realm. Categorical approaches are unlikely to be fruitful as one should not expect to find a single or even predominant underlying cause of autism behavior across individuals. It is possible that the complex, highly interactive, heterogeneous and individualistic nature of the autism realm is intractable in terms of identifying clinically useful biomarker tests. It is hopeful from an emergenic perspective that small corrective changes in a single component of a deleterious network/configuration might have large beneficial consequences on developmental trajectories and in later treatment. It is suggested that the relationship between ASD and intellectual disability might be fundamentally different in single-gene versus nonsyndromic ASD. It is strongly stated that available biomarker "tests" for autism/ASD will do more harm than good. Finally, the serotonin-melatonin-oxidative stress-placental intersection might be an especially fruitful area of biological investigation.
Descriptors: Autism, Pervasive Developmental Disorders, Genetics, Mental Retardation, Clinical Diagnosis, Networks
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Publication Type: Journal Articles; Reports - Descriptive
Education Level: N/A
Authoring Institution: N/A