ERIC Number: EJ1052993
Record Type: Journal
Publication Date: 2015-Mar
Abstractor: As Provided
Reference Count: 49
DSM-5 Changes and the Prevalence of Parent-Reported Autism Spectrum Symptoms in Fragile X Syndrome
Wheeler, Anne C.; Mussey, Joanna; Villagomez, Adrienne; Bishop, Ellen; Raspa, Melissa; Edwards, Anne; Bodfish, James; Bann, Carla; Bailey, Donald B.
Journal of Autism and Developmental Disorders, v45 n3 p816-829 Mar 2015
We used survey methodology to assess parent-reported autism symptomology in 758 individuals (639 males; 119 females) with fragile X syndrome (FXS). Caregivers reported whether their child with FXS had been diagnosed with an autism spectrum disorder (ASD) and endorsed symptoms based on a list of observable behaviors related to ASD diagnoses. Symptom counts were categorized based on "DSM-IV-TR" and "DSM-5" criteria. Based on behavioral symptoms endorsed by caregivers, 38.7% of males and 24.7% of females met criteria for "DSM-IV-TR" diagnosis of autistic disorder. Significantly fewer males (27.8%) and females (11.3%) met criteria for ASD based on "DSM-5" criteria. Although 86.4% of males and 61.7% of females met criteria for the restricted and repetitive behavior domain for DSM-5, only 29.4% of males and 13.0% of females met criteria for the social communication and interaction (SCI) domain. Relaxing the social communication criteria by one symptom count led to a threefold increase in those meeting criteria for ASD, suggesting the importance of subthreshold SCI symptoms for individuals with FXS in ASD diagnoses. Findings suggest important differences in the way ASD may be conceptualized in FXS based on the new DSM-5 criteria.
Descriptors: Genetic Disorders, Autism, Pervasive Developmental Disorders, Symptoms (Individual Disorders), Surveys, Children, Clinical Diagnosis, Behavior Problems, Gender Differences, Interpersonal Competence, Interaction, Interpersonal Communication, Incidence, Parents
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A