Safer sex is important for protection against STDs and HIV/AIDS. Most of the HIV-related research is targeted towards high-risk groups such as prostitutes, gays and substance abusers there is evidence that HIV/AIDS is increasing in college students particularly among African-American college students. The purpose of this study was to study predictors of safer sex behaviors among African-American college students using social cognitive theory. A cross-sectional survey design was used in this study with valid and reliable subscales. All data were analyzed by the Statistical Package for Social Sciences (SPSS), Version 16. For modeling the predictors of safer sex, stepwise multiple regression was used. Self-efficacy toward safer sex predicted 14.7% variance in safer sex. Recommendations for designing safer sex interventions are presented.