ERIC Number: EJ1049219
Record Type: Journal
Publication Date: 2015-Jan
Abstractor: As Provided
Reference Count: 64
Genetic Variation in Melatonin Pathway Enzymes in Children with Autism Spectrum Disorder and Comorbid Sleep Onset Delay
Veatch, Olivia J.; Pendergast, Julie S.; Allen, Melissa J.; Leu, Roberta M.; Johnson, Carl Hirschie; Elsea, Sarah H.; Malow, Beth A.
Journal of Autism and Developmental Disorders, v45 n1 p100-110 Jan 2015
Sleep disruption is common in individuals with autism spectrum disorder (ASD). Genes whose products regulate endogenous melatonin modify sleep patterns and have been implicated in ASD. Genetic factors likely contribute to comorbid expression of sleep disorders in ASD. We studied a clinically unique ASD subgroup, consisting solely of children with comorbid expression of sleep onset delay. We evaluated variation in two melatonin pathway genes, "acetylserotonin O-methyltransferase" ("ASMT") and cytochrome "P450 1A2" ("CYP1A2"). We observed higher frequencies than currently reported (p < 0.04) for variants evidenced to decrease "ASMT" expression and related to decreased "CYP1A2" enzyme activity (p = 0.0007). We detected a relationship between genotypes in "ASMT" and "CYP1A2" (r[superscript 2] = 0.63). Our results indicate that expression of sleep onset delay relates to melatonin pathway genes.
Descriptors: Pervasive Developmental Disorders, Autism, Sleep, Genetics, Children, Metabolism, Correlation
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A