ERIC Number: EJ1048867
Record Type: Journal
Publication Date: 2015-Jan
Abstractor: As Provided
Reference Count: N/A
Immediate-Early Gene Transcriptional Activation in Hippocampus Ca1 and Ca3 Does Not Accurately Reflect Rapid, Pattern Completion-Based Retrieval of Context Memory
Pevzner, Aleksandr; Guzowski, John F.
Learning & Memory, v22 n1 p1-5 Jan 2015
No studies to date have examined whether immediate-early gene (IEG) activation is driven by context memory recall. To address this question, we utilized the context preexposure facilitation effect (CPFE) paradigm. In CPFE, animals acquire contextual fear conditioning through hippocampus-dependent rapid retrieval of a previously formed contextual representation. Despite differences in behavior, we did not find any difference in CA1 or CA3 IEG activity associated with this rapid recall phase when comparing context preexposed and non-pre-exposed groups. These findings indicate that IEG activation in CA1 and CA3 is not an accurate readout of the neural activity associated with hippocampus-dependent rapid memory retrieval.
Descriptors: Genetics, Correlation, Recall (Psychology), Context Effect, Conditioning, Comparative Analysis, Fear, Brain Hemisphere Functions, Animals, Animal Behavior
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A