ERIC Number: EJ1047150
Record Type: Journal
Publication Date: 2014-Dec
Abstractor: As Provided
Exercise and Type 2 Diabetes: Molecular Mechanisms Regulating Glucose Uptake in Skeletal Muscle
Stanford, Kristin I.; Goodyear, Laurie J.
Advances in Physiology Education, v38 n4 p308-314 Dec 2014
Exercise is a well-established tool to prevent and combat type 2 diabetes. Exercise improves whole body metabolic health in people with type 2 diabetes, and adaptations to skeletal muscle are essential for this improvement. An acute bout of exercise increases skeletal muscle glucose uptake, while chronic exercise training improves mitochondrial function, increases mitochondrial biogenesis, and increases the expression of glucose transporter proteins and numerous metabolic genes. This review focuses on the molecular mechanisms that mediate the effects of exercise to increase glucose uptake in skeletal muscle.
Descriptors: Exercise, Diabetes, Muscular Strength, Prevention, Physiology, Molecular Structure, Genetics, Metabolism
American Physiological Society. 9650 Rockville Pike, Bethesda, MD 20814-3991. Tel: 301-634-7164; Fax: 301-634-7241; e-mail: firstname.lastname@example.org; Web site: http://advan.physiology.org/
Publication Type: Journal Articles; Information Analyses; Reports - Evaluative
Education Level: N/A
Sponsor: National Institutes of Health (DHHS)
Authoring Institution: N/A
Grant or Contract Numbers: R01-AR-42238; R01-DK-101043; 5-P30-DK-36836