This paper proposes a personalised instructional strategy, "student-selected vocabulary," to facilitate secondary school students' vocabulary building. It then reports how this personalised instructional strategy was implemented and evaluated through a teacher-led intervention study of 57 low-achieving Hong Kong secondary school students. Data were collected with multiple measures: student-made vocabulary cards, paper questionnaires, and personalised vocabulary tests. The findings show that these low-achieving students selected words to learn in a responsible way to meet with their academic needs and achieved good retention rates of their personalised curriculum. Evidence also shows that learner differences were catered for and well addressed in this innovative personalised vocabulary pedagogy.