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ERIC Number: EJ1046277
Record Type: Journal
Publication Date: 2014-Nov
Pages: 4
Abstractor: As Provided
ISSN: ISSN-0021-9584
Mechanical Modeling and Computer Simulation of Protein Folding
Prigozhin, Maxim B.; Scott, Gregory E.; Denos, Sharlene
Journal of Chemical Education, v91 n11 p1939-1942 Nov 2014
In this activity, science education and modern technology are bridged to teach students at the high school and undergraduate levels about protein folding and to strengthen their model building skills. Students are guided from a textbook picture of a protein as a rigid crystal structure to a more realistic view: proteins are highly dynamic biological molecules in the heterogeneous environment inside the living cell. Simple mechanical models and computer simulations that evolve in their complexity as the instruction progresses are at the core of this lesson. Methods of statistics and physical chemistry (thermodynamics and kinetics) are employed to investigate a flexible version of a peptide that can sample various conformations within the folded ensemble and ultimately unfold into a random coil.
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education; High Schools; Secondary Education
Audience: N/A
Language: English
Sponsor: National Science Foundation
Authoring Institution: N/A
Grant or Contract Numbers: 1430124