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ERIC Number: EJ1044400
Record Type: Journal
Publication Date: 2014-Aug
Pages: 9
Abstractor: As Provided
Reference Count: 15
ISBN: N/A
ISSN: ISSN-0002-7685
Drug-Resistant Tuberculosis: A Genetic Analysis Using Online Bioinformatics Tools
Taylor, Jessica M.; Davidson, Rebecca M.; Strong, Michael
American Biology Teacher, v76 n6 p386-394 Aug 2014
Tuberculosis (TB) continues to be a serious global health problem, resulting in >1.4 million deaths each year. Of increasing concern is the evolution of antibiotic resistant strains of the bacterium that causes TB. Using this real-world scenario, we created a 90-minute activity for high school or undergraduate students to use online bioinformatics tools to detect single-nucleotide polymorphisms (SNPs) between a wild-type and a variant "Mycobacterium tuberculosis" gene that could confer resistance to a commonly used TB antibiotic, rifampin. Students write a scientific explanation, providing evidence and reasoning, to support their claim of antibiotic resistance or susceptibility. The entire lesson can be found online at http://www.stronglab.org/taylor.
University of California Press. 2000 Center Street Suite 303, Berkeley, CA 94704. Tel: 510-643-7154; Fax: 510-642-9917; e-mail: customerservice@ucpressjournals.com; Web site: http://www.ucpressjournals.com/journal.php?j=abt
Publication Type: Journal Articles; Reports - Research; Tests/Questionnaires
Education Level: High Schools; Secondary Education; Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID/NIH)
Authoring Institution: N/A
IES Grant or Contract Numbers: R25AI080566