NotesFAQContact Us
Search Tips
Peer reviewed Peer reviewed
Direct linkDirect link
ERIC Number: EJ1044400
Record Type: Journal
Publication Date: 2014-Aug
Pages: 9
Abstractor: As Provided
Reference Count: 15
ISSN: ISSN-0002-7685
Drug-Resistant Tuberculosis: A Genetic Analysis Using Online Bioinformatics Tools
Taylor, Jessica M.; Davidson, Rebecca M.; Strong, Michael
American Biology Teacher, v76 n6 p386-394 Aug 2014
Tuberculosis (TB) continues to be a serious global health problem, resulting in >1.4 million deaths each year. Of increasing concern is the evolution of antibiotic resistant strains of the bacterium that causes TB. Using this real-world scenario, we created a 90-minute activity for high school or undergraduate students to use online bioinformatics tools to detect single-nucleotide polymorphisms (SNPs) between a wild-type and a variant "Mycobacterium tuberculosis" gene that could confer resistance to a commonly used TB antibiotic, rifampin. Students write a scientific explanation, providing evidence and reasoning, to support their claim of antibiotic resistance or susceptibility. The entire lesson can be found online at
University of California Press. 2000 Center Street Suite 303, Berkeley, CA 94704. Tel: 510-643-7154; Fax: 510-642-9917; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Research; Tests/Questionnaires
Education Level: High Schools; Secondary Education; Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID/NIH)
Authoring Institution: N/A
IES Grant or Contract Numbers: R25AI080566