ERIC Number: EJ1042877
Record Type: Journal
Publication Date: 2014-Nov
Abstractor: As Provided
Reference Count: 100
White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder
Cooper, Miriam; Thapar, Anita; Jones, Derek K.
Journal of Autism and Developmental Disorders, v44 n11 p2742-2754 Nov 2014
Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations (p < 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case-control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD.
Descriptors: Autism, Pervasive Developmental Disorders, Symptoms (Individual Disorders), Attention Deficit Hyperactivity Disorder, Males, Adolescents, Comparative Analysis, Correlation, Severity (of Disability), Brain Hemisphere Functions, Comorbidity
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A