ERIC Number: EJ1041161
Record Type: Journal
Publication Date: 2014-Oct
Abstractor: As Provided
Reference Count: 26
Expression of the Broad Autism Phenotype in Simplex Autism Families from the Simons Simplex Collection
Davidson, Julie; Goin-Kochel, Robin P.; Green-Snyder, Lee Anne; Hundley, Rachel J.; Warren, Zachary; Peters, Sarika U.
Journal of Autism and Developmental Disorders, v44 n10 p2392-2399 Oct 2014
The broad autism phenotype (BAP) refers to the phenotypic expression of an underlying genetic liability to autism, manifest in non-autistic relatives. This study examined the relationship among the "Broad Autism Phenotype Questionnaire" (BAPQ), "Social Responsiveness Scale: Adult Research Version" (SRS:ARV), and "Family History Interview" (FHI) in a large, multi-site study of 1,650 simplex families (Simons Simplex Collection). Correlations between the BAPQ and SRS:ARV Total scores were moderate, and correlations between FHI ratings and SRS:ARV and BAPQ were significant but weak. Overall, the results suggested that BAP traits occur at low rates in simplex families, and rates vary significantly depending upon the measure utilized. Implications include the need for multiple informants, and the assessment of distinct BAP traits in large-scale genetic studies of individuals with ASD.
Descriptors: Genetic Disorders, Autism, Correlation, Questionnaires, Family (Sociological Unit), Heredity, Pervasive Developmental Disorders, Scores, Symptoms (Individual Disorders), Social Development
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A