Given the prevalence of school-age children and adolescents who are prescribed with and are taking psychotropic medications, a critical issue that school psychologists may likely encounter in contemporary practice is providing both quality and continuity of care to these students in the context of relevant legal and ethical parameters. With a thorough understanding of federal, state, and local legislation, relevant case law, and ethical standards, school psychologists are well positioned to competently navigate these situations in school-based practice. This article highlights critical practice roles for school psychologists to undertake in working with students who are prescribed with and are taking psychotropic medications within the school setting.