ERIC Number: EJ1040324
Record Type: Journal
Publication Date: 2014-Sep
Abstractor: As Provided
Reference Count: 17
A Three-Step Synthesis of Benzoyl Peroxide
Her, Brenda; Jones, Alexandra; Wollack, James W.
Journal of Chemical Education, v91 n9 p1491-1494 Sep 2014
Benzoyl peroxide is used as a bleaching agent for flour and whey processing, a polymerization initiator in the synthesis of plastics, and the active component of acne medication. Because of its simplicity and wide application, benzoyl peroxide is a target molecule of interest. It can be affordably synthesized in three steps from bromobenzene using procedures that can be performed in four, 4 h laboratory periods. This process includes a Grignard reaction to turn bromobenzene into benzoic acid, nucleophilic acyl substitution to transform the resulting carboxylic acid into an acid chloride, and the addition of H[subscript 2]O[subscript 2]/NaOH to the acid chloride to yield benzoyl peroxide. Most organic chemistry students are familiar with these traditional reaction mechanisms because they are covered in introductory organic chemistry courses. The starting materials for each reaction are commercially available, and the products can be readily characterized using NMR spectroscopy, IR spectroscopy, and melting point.
Descriptors: Chemistry, Organic Chemistry, Spectroscopy, College Science, Science Instruction, Science Activities, Science Experiments, Laboratory Procedures, Laboratory Safety, Laboratory Experiments
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Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Authoring Institution: N/A