Hope is positively correlated with educational attainment and health. Interventions based on project-based learning (PBL) may increase youth hope. This study examined how a PBL intervention affected hope among urban students of color. Students in health classes were invited to participate. A PBL health class was implemented in four classrooms. The standard curriculum was implemented in four control classrooms. Questionnaires with measures of hope were administered at three time points. Generalized linear modeling examined the intervention effect on hope. There were no intervention effects on hope. There were significant differences in hope between certain racial and ethnic groups. One PBL class may not increase hope among urban students of color. Research should identify approaches that enhance hope in order to increase educational attainment and health.