ERIC Number: EJ1038336
Record Type: Journal
Publication Date: 2014-Jul
Abstractor: As Provided
Reference Count: 50
Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11
Nijmeijer, Judith S.; Arias-Vásquez, Alejandro; Rommelse, Nanda N.; Altink, Marieke E.; Buschgens, Cathelijne J.; Fliers, Ellen A.; Franke, Barbara; Minderaa, Ruud B.; Sergeant, Joseph A.; Buitelaar, Jan K.; Hoekstra, Pieter J.; Hartman, Catharina A.
Journal of Autism and Developmental Disorders, v44 n7 p1671-1680 Jul 2014
We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children's Social Behavior Questionnaire (CSBQ) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing.
Descriptors: Attention Deficit Hyperactivity Disorder, Comorbidity, Siblings, Autism, Pervasive Developmental Disorders, Genetic Disorders, Social Behavior, Interaction, Interpersonal Competence, Genetics, Symptoms (Individual Disorders), Questionnaires
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
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