ERIC Number: EJ1037911
Record Type: Journal
Publication Date: 2013-Oct
Abstractor: As Provided
Reference Count: 41
Systematic Review and Meta-Analysis of Pharmacological Treatment of the Symptoms of Attention-Deficit/Hyperactivity Disorder in Children with Pervasive Developmental Disorders
Reichow, Brian; Volkmar, Fred R.; Bloch, Michael H.
Journal of Autism and Developmental Disorders, v43 n10 p2435-2441 Oct 2013
Many children with pervasive developmental disorders (PDD) exhibit behaviors and symptoms of attention-deficit/hyperactivity disorder (ADHD). We sought to determine the relative efficacy of medications for treating ADHD symptoms in children with PDD by identifying all double-blind, randomized, placebo-controlled trials examining the efficacy of medications for treating ADHD symptoms in children with PDD. We located seven trials involving 225 children. A random effects meta-analysis of four methylphenidate trials showed methylphenidate to be effective for treating ADHD symptoms in children with PDD (ES = 0.67). Several adverse events were greater for children were taking methylphenidate compared to placebo. An individual trial of clonidine and two trials of atomoxetine suggest these agents may also be effective in treating ADHD symptoms in children with PDD.
Descriptors: Autism, Pervasive Developmental Disorders, Drug Therapy, Outcomes of Treatment, Attention Deficit Hyperactivity Disorder, Children, Symptoms (Individual Disorders), Comorbidity, Meta Analysis, Stimulants
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A