ERIC Number: EJ1037886
Record Type: Journal
Publication Date: 2013-Aug
Abstractor: As Provided
Reference Count: 119
Psychological Correlates of Handedness and Corpus Callosum Asymmetry in Autism: The Left Hemisphere Dysfunction Theory Revisited
Floris, Dorothea L.; Chura, Lindsay R.; Holt, Rosemary J.; Suckling, John; Bullmore, Edward T.; Baron-Cohen, Simon; Spencer, Michael D.
Journal of Autism and Developmental Disorders, v43 n8 p1758-1772 Aug 2013
Rightward cerebral lateralization has been suggested to be involved in the neuropathology of autism spectrum conditions. We investigated functional and neuroanatomical asymmetry, in terms of handedness and corpus callosum measurements in male adolescents with autism, their unaffected siblings and controls, and their associations with executive dysfunction and symptom severity. Adolescents with autism did not differ from controls in functional asymmetry, but neuroanatomically showed the expected pattern of stronger rightward lateralization in the posterior and anterior midbody based on their hand-preference. Measures of symptom severity were related to rightward asymmetry in three subregions (splenium, posterior midbody and rostral body). We found the opposite pattern for the isthmus and rostrum with better cognitive and less severe clinical scores associated with rightward lateralization.
Descriptors: Brain Hemisphere Functions, Autism, Pervasive Developmental Disorders, Handedness, Males, Adolescents, Siblings, Control Groups, Correlation, Executive Function, Symptoms (Individual Disorders), Neurological Impairments, Severity (of Disability)
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A