ERIC Number: EJ1037809
Record Type: Journal
Publication Date: 2013-Jul
Abstractor: As Provided
Reference Count: 35
Maternal Vitamin D Levels and the Autism Phenotype among Offspring
Whitehouse, Andrew J. O.; Holt, Barbara J.; Serralha, Michael; Holt, Patrick G.; Hart, Prue H.; Kusel, Merci M. H.
Journal of Autism and Developmental Disorders, v43 n7 p1495-1504 Jul 2013
We tested whether maternal vitamin D insufficiency during pregnancy is related to the autism phenotype. Serum 25(OH)-vitamin D concentrations of 929 women were measured at 18 weeks' pregnancy. The mothers of the three children with a clinical diagnosis of autism spectrum disorder had 25(OH)-vitamin D concentrations above the population mean. The offspring of 406 women completed the Autism-Spectrum Quotient in early adulthood. Maternal 25(OH)-vitamin D concentrations were unrelated to offspring scores on the majority of scales. However, offspring of mothers with low 25(OH)-vitamin D concentrations (<49 nmol/L) were at increased risk for "high" scores (=2SD above mean) on the Attention Switching subscale (odds ratio: 5.46, 95% confidence interval: 1.29, 23.05). The involvement of maternal vitamin D during pregnancy in autism requires continued investigation.
Descriptors: Nutrition, Pregnancy, Prenatal Influences, Autism, Mothers, Pervasive Developmental Disorders, Young Adults, Attention, Symptoms (Individual Disorders)
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A