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ERIC Number: EJ1037798
Record Type: Journal
Publication Date: 2013-Nov
Pages: 9
Abstractor: As Provided
Reference Count: 43
ISBN: N/A
ISSN: ISSN-0162-3257
Autism and Phthalate Metabolite Glucuronidation
Stein, T. Peter; Schluter, Margaret D.; Steer, Robert A.; Ming, Xue
Journal of Autism and Developmental Disorders, v43 n11 p2677-2685 Nov 2013
Exposure to environmental chemicals may precipitate autism spectrum disorders (ASD) in genetically susceptible children. Differences in the efficiency of the glucuronidation process may substantially modulate substrate concentrations and effects. To determine whether the efficiency of this pathway is compromised in children with ASD, we measured the efficiency of glucuronidation for a series of metabolites derived from the commonly used plasticizer, diethylhexyl phthalate. Spot urines were collected and analyzed for the fraction of each metabolite conjugated by isotope dilution-liquid chromatography mass spectrometry-mass spectrometry. The degree of glucuronidation was lower with the ASD group. The glucuronidation pathway may differ in some children with ASD.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A