NotesFAQContact Us
Collection
Advanced
Search Tips
Peer reviewed Peer reviewed
Direct linkDirect link
ERIC Number: EJ1037112
Record Type: Journal
Publication Date: 2014-Aug
Pages: 13
Abstractor: As Provided
Reference Count: 89
ISBN: N/A
ISSN: ISSN-0162-3257
A Twin Study of Heritable and Shared Environmental Contributions to Autism
Frazier, Thomas W.; Thompson, Lee; Youngstrom, Eric A.; Law, Paul; Hardan, Antonio Y.; Eng, Charis; Morris, Nathan
Journal of Autism and Developmental Disorders, v44 n8 p2013-2025 Aug 2014
The present study examined genetic and shared environment contributions to quantitatively-measured autism symptoms and categorically-defined autism spectrum disorders (ASD). Participants included 568 twins from the Interactive Autism Network. Autism symptoms were obtained using the Social Communication Questionnaire and Social Responsiveness Scale. Categorically-defined ASD was based on clinical diagnoses. DeFries-Fulker and liability threshold models examined etiologic influences. Very high heritability was observed for extreme autism symptom levels (h[superscript 2][subscript g] = 0.92-1.20). Extreme levels of social and repetitive behavior symptoms were strongly influenced by common genetic factors. Heritability of categorically-defined ASD diagnosis was comparatively low (0.21, 95% CI 0.15-0.28). High heritability of extreme autism symptom levels confirms previous observations of strong genetic influences on autism. Future studies will require large, carefully ascertained family pedigrees and quantitative symptom measurements.
Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A