ERIC Number: EJ1037073
Record Type: Journal
Publication Date: 2014-Aug
Abstractor: As Provided
Reference Count: 79
Downregulation of GABA[Subscript A] Receptor Protein Subunits a6, ß2, d, e, ?2, ?, and ?2 in Superior Frontal Cortex of Subjects with Autism
Fatemi, S. Hossein; Reutiman, Teri J.; Folsom, Timothy D.; Rustan, Oyvind G.; Rooney, Robert J.; Thuras, Paul D.
Journal of Autism and Developmental Disorders, v44 n8 p1833-1845 Aug 2014
We measured protein and mRNA levels for nine gamma-aminobutyric acid A (GABA[subscript A]) receptor subunits in three brain regions (cerebellum, superior frontal cortex, and parietal cortex) in subjects with autism versus matched controls. We observed changes in mRNA for a number of GABA[subscript A] and GABA[subscript B] subunits and overall reduced protein expression for GABA[subscript A] receptor alpha 6 (GABRa6), GABA[subscript A] receptor beta 2 (GABRß2), GABA[subscript A] receptor delta (GABRd), GABA[subscript A] receptor epsilon (GABRe), GABA[subscript A] receptor gamma 2 (GABR?2), GABA[subscript A] receptor theta (GABR?), and GABA[subscript A] receptor rho 2 (GABR?2) in superior frontal cortex from subjects with autism. Our data demonstrate systematic changes in GABA[subscript A&B] subunit expression in brains of subjects with autism, which may help explain the presence of cognitive abnormalities in subjects with autism.
Descriptors: Brain, Autism, Brain Hemisphere Functions, Comparative Analysis, Neurological Impairments
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A