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ERIC Number: EJ1036353
Record Type: Journal
Publication Date: 2014-Aug
Pages: 4
Abstractor: As Provided
Reference Count: 38
ISSN: ISSN-0021-9584
Simulated Analysis of Linear Reversible Enzyme Inhibition with SCILAB
Antuch, Manuel; Ramos, Yaquelin; Álvarez, Rubén
Journal of Chemical Education, v91 n8 p1203-1206 Aug 2014
SCILAB is a lesser-known program (than MATLAB) for numeric simulations and has the advantage of being free software. A challenging software-based activity to analyze the most common linear reversible inhibition types with SCILAB is described. Students establish typical values for the concentration of enzyme, substrate, and inhibitor to simulate realistic kinetic data. To extract kinetic parameters, linear and nonlinear (hyperbolic) data fitting are used. The actual distinction between competitive and mixed-type inhibitions and between noncompetitive and mixed-type inhibitions is discussed on the basis of nonlinear data fitting. The activity was performed as a part of an advanced undergraduate course, "Chemical Kinetics", and added to students' diverse preexisting knowledge.
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A