ERIC Number: EJ1035402
Record Type: Journal
Publication Date: 2014-May
Abstractor: As Provided
Reference Count: N/A
Early-Life Cocaine Interferes with BDNF-Mediated Behavioral Plasticity
Hinton, Elizabeth A.; Wheeler, Marina G.; Gourley, Shannon L.
Learning & Memory, v21 n5 p253-257 May 2014
An important aspect of goal-directed action selection is differentiating between actions that are more or less likely to be reinforced. With repeated performance or psychostimulant exposure, however, actions can assume stimulus-elicited--or "habitual"--qualities that are resistant to change. We show that selective knockdown of prelimbic prefrontal cortical "Brain-derived neurotrophic factor" ("Bdnf") increases sensitivity to response-outcome associations, blocking habit-like behavioral inflexibility. A history of adolescent cocaine exposure, however, occludes the "beneficial" effects of "Bdnf" knockdown. This finding highlights a challenge in treating addiction--that drugs of abuse may bias decision-making toward habit systems even in individuals with putative neurobiological resiliencies.
Descriptors: Cocaine, Goal Orientation, Reinforcement, Stimulants, Brain Hemisphere Functions, Neurological Impairments, Responses, Behavior, Adolescents, Behavioral Science Research, Addictive Behavior, Drug Abuse
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A