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ERIC Number: EJ1032462
Record Type: Journal
Publication Date: 2014-Jun
Pages: 4
Abstractor: As Provided
Reference Count: 16
ISBN: N/A
ISSN: ISSN-0021-9584
Determination of Log K[subscript ow] Values for Four Drugs
Harris, Mark F.; Logan, Jennifer L.
Journal of Chemical Education, v91 n6 p915-918 Jun 2014
Though many undergraduates are interested in medicine, relatively few experiments related to drug design and development are included in introductory chemistry laboratory courses. In this experiment, aqueous solutions of four different drugs (acetaminophen, caffeine, phenacetin, and sulfanilamide) are extracted using 1-octanol, a mimic of the amphiphilic lipids that constitute cell membranes. UV analysis of the aqueous solutions before and after extraction allows determination of each compound's log K[subscript ow] value (partition coefficient), a property that influences a drug's bioavailability. The concepts of equilibrium and hydrophobicity-hydrophilicity are emphasized, and students gain experience with micropipets in making dilutions. The lab has been implemented in a second-year undergraduate analytical chemistry course but may be suitable for organic, general, or medicinal chemistry depending on an institution's particular curriculum.
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A