The aim of this study was to determine the opinions and self-evaluation of the students of Geography Department about the applications of Cooperative Learning in Regional Geography course. The study was carried out for twelve weeks with 76 students who are in the Department of Geography, Faculty of Arts, Karabuk University between 2011-12. In this study, descriptive survey model and content analysis were used along with opinion surveys towards cooperative learning, self-evaluation scale, and open-ended semi-structured questionnaire about the applications to collect the data. In the analysis of quantitative data mean, standard deviance, and t-test were applied, while in the analysis of qualitative data content analysis was applied. At the end of the research the students of Geography Department declared that their interest and participation in the course were increased, their social aspects were improved, the lectures were entertaining and there was a positive atmosphere in the classroom thanks to the applications of cooperative learning. In the self-evaluation about the applications, the students stated that most of the students came to class with preparations, they used various resources while preparing a presentation, they carried out their individual responsibilities in the group work and they did their best for the sake of the group's success.