ERIC Number: EJ1027454
Record Type: Journal
Publication Date: 2014
Abstractor: As Provided
Reference Count: N/A
How and Why Does the 5-HTTLPR Gene Moderate Associations between Maternal Unresponsiveness and Children's Disruptive Problems?
Davies, Patrick T.; Cicchetti, Dante
Child Development, v85 n2 p484-500 Mar-Apr 2014
This study tested the 5-HTTLPR gene as a moderator in the relation between maternal unresponsiveness and child externalizing symptoms in a disadvantaged, predominantly Black sample of two hundred and one 2-year-old children and their mothers. Using a multimethod, prospective design, structural equation model analyses indicated that maternal unresponsiveness significantly predicted increases in externalizing symptoms 2 years later only for children possessing the LL genotype. Moderation was expressed in a "for better" or "for worse" form hypothesized in differential susceptibility theory. In examining why the risk posed by maternal unresponsiveness differed across the 5-HTTLPR polymorphism, mediated moderation analyses showed that children's angry reactivity to maternal negativity partly accounted for the greater susceptibility of homozygous L carriers to variations in maternal unresponsiveness.
Descriptors: Genetics, Mothers, Parent Child Relationship, Affective Behavior, Behavior Problems, Disadvantaged Youth, African Americans, Young Children, Toddlers, Structural Equation Models, Predictor Variables, Symptoms (Individual Disorders), Hypothesis Testing, At Risk Persons, Responses, Psychological Patterns
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Publication Type: Journal Articles; Reports - Research
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