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ERIC Number: EJ1027269
Record Type: Journal
Publication Date: 2014-Apr
Pages: 8
Abstractor: As Provided
Reference Count: N/A
ISSN: ISSN-1072-0502
A Novel Cysteine-Rich Neurotrophic Factor in "Aplysia" Facilitates Growth, MAPK Activation, and Long-Term Synaptic Facilitation
Pu, Lu; Kopec, Ashley M.; Boyle, Heather D.; Carew, Thomas J.
Learning & Memory, v21 n4 p215-222 Apr 2014
Neurotrophins are critically involved in developmental processes such as neuronal cell survival, growth, and differentiation, as well as in adult synaptic plasticity contributing to learning and memory. Our previous studies examining neurotrophins and memory formation in "Aplysia" showed that a TrkB ligand is required for MAPK activation, long-term synaptic facilitation (LTF), and long-term memory (LTM) for sensitization. These studies indicate that neurotrophin-like molecules in "Aplysia" can act as key elements in a functionally conserved TrkB signaling pathway. Here we report that we have cloned and characterized a novel neurotrophic factor, "Aplysia" cysteine-rich neurotrophic factor (apCRNF), which shares classical structural and functional characteristics with mammalian neurotrophins. We show that apCRNF (1) is highly enriched in the CNS, (2) enhances neurite elongation and branching, (3) interacts with mammalian TrkB and p75 [superscript NTR], (4) is released from "Aplysia" CNS in an activity-dependent fashion, (5) facilitates MAPK activation in a tyrosine kinase dependent manner in response to sensitizing stimuli, and (6) facilitates the induction of LTF. These results show that apCRNF is a native neurotrophic factor in "Aplysia" that can engage the molecular and synaptic mechanisms underlying memory formation.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: N/A
Sponsor: N/A
Authoring Institution: N/A