This study examines and discusses dropping out of school related to adolescents with social, emotional and behavioural difficulties (SEBD). It is based on in-depth interviews of 10 adolescents between the ages of 16 and 20, three girls and two boys with internalised problems, and two girls and three boys with extroverted behavioural problems. Given this group of students' challenges at school, the aim of this paper is to explore the narratives of this adolescent group as they relate to the significance they attach to their dropout behaviour. An additional objective is to draw attention to what these findings are likely to mean for implementing preventive practices in school. Results show that adolescents with SEBD perceive a non-supportive classroom environment to be a primary explanation for why they are dropping out from school. Additionally, lack of support from teachers and parents and family problems are, according to the adolescents, an important reason for dropping out. Findings are discussed in relation to future implications for this group of adolescents in the context of school.