ERIC Number: EJ1023202
Record Type: Journal
Publication Date: 2014
Abstractor: As Provided
Reference Count: 17
Amygdala Activation and Emotional Processing in Adolescents at Risk for Substance Use Disorders
Lindsay, Dawn L.; Pajtek, Stefan; Tarter, Ralph E.; Long, Elizabeth C.; Clark, Duncan B.
Journal of Child & Adolescent Substance Abuse, v23 n3 p200-204 2014
Studies are needed that examine neurobiological characteristics in high-risk individuals prior to substance use disorder (SUD) development. In this pilot study, 4 adolescent subjects at high risk for SUD (having at least 1 parent with an SUD) were compared with 4 adolescent reference subjects on a cortico-limbic reactivity paradigm, where they were presented with affect-laden faces or geometric shapes. Functional magnetic resonance imaging was used to measure cortical activation in response to these stimuli. High-risk subjects, compared to low-risk, exhibited greater left amygdala activation ("t" = 2.76, "df" = 6, "p" = 0.03), suggesting they may exhibit hyperresponsivity of the amygdala in response to emotional stimuli.
Descriptors: Brain Hemisphere Functions, Emotional Response, Cognitive Processes, Adolescents, At Risk Persons, Substance Abuse, Comparative Analysis, Visual Stimuli, Diagnostic Tests, Responses, Affective Behavior
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A
Identifiers - Location: Pennsylvania