Today's scientist is faced with complex problems that require interdisciplinary solutions. Consequently, tertiary science educators have had to develop and deliver interdisciplinary science courses to equip students with the skills required to solve the evolving real-world challenges of today and tomorrow. There are few reported studies of the lessons learned from designing and delivering first year compulsory interdisciplinary science subjects at regional universities. Even fewer studies assess the impact that teaching interventions within interdisciplinary courses have on students' attitudes towards mathematics and technology, and mathematics anxiety. This paper discusses the feedback received from the first student cohort of a new compulsory, first year interdisciplinary science subject at a regional Australian university which resulted in curricular revisions. These revisions included a greater emphasis on the subject relevance and increased student support in tutorials. Assessment practices were also dramatically modified. The change in student attitudes and anxiety levels "a priori" and "a posteriori" to the interventions was measured quantitatively and qualitatively. Post-intervention, female and non-mathematics major students had grown in mathematical confidence and were less anxious. It is important that positive and negative research findings are reported, so science educators can learn from one another, and can better prepare their students for the challenges they will face in bringing interdisciplinary solutions to contemporary real-world problems.