Pre-service teacher training has been identified as one of the key factors in the promotion of inclusive education. In this study, 200 final-year pre-service teachers from three colleges of education in Ghana were surveyed about their views and knowledge on inclusive education and special educational needs (SEN). The results showed that almost all of the participants had been introduced to the concept of inclusion during their studies. However, only one-third felt highly, or somewhat, prepared to teach children with SEN. The level of knowledge and feelings of self-efficacy were highest among those pre-service teachers who had personal experience of supporting children with SEN during their practicum. The participants tended to prefer those inclusive instructional strategies that were easiest to apply in general education classrooms. Significant differences in the outcomes were found between the three colleges studied indicating strong effects of the teacher education model applied in each college.