ERIC Number: EJ1020917
Record Type: Journal
Publication Date: 2013-Nov
Abstractor: As Provided
Sex Differences in the Generalization of Fear as a Function of Retention Intervals
Lynch, Joseph, III; Cullen, Patrick K.; Jasnow, Aaron M.; Riccio, David C.
Learning & Memory, v20 n11 p628-632 Nov 2013
In previous studies using male rodents, context change disrupted a fear response at a short, but not a long, retention interval. Here, we examined the effects of context changes on fear responses as a function of time in male and female rats. Males displayed context discrimination at all intervals, whereas females exhibited generalization by 5 d. Ovariectomized females with no hormone replacement displayed context discrimination at 5 d, whereas those receiving 17ß-estradiol generalized their fear response to a neutral context. These results demonstrate that fear generalization for contextual cues occurs faster in female rats and is mediated, in part, by estrogens.
Descriptors: Gender Differences, Generalization, Fear, Retention (Psychology), Memory, Animals, Intervals, Context Effect, Metabolism, Cues
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: firstname.lastname@example.org; Web site: http://www.learnmem.org/
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A