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ERIC Number: EJ1020917
Record Type: Journal
Publication Date: 2013-Nov
Pages: 5
Abstractor: As Provided
ISSN: ISSN-1072-0502
Sex Differences in the Generalization of Fear as a Function of Retention Intervals
Lynch, Joseph, III; Cullen, Patrick K.; Jasnow, Aaron M.; Riccio, David C.
Learning & Memory, v20 n11 p628-632 Nov 2013
In previous studies using male rodents, context change disrupted a fear response at a short, but not a long, retention interval. Here, we examined the effects of context changes on fear responses as a function of time in male and female rats. Males displayed context discrimination at all intervals, whereas females exhibited generalization by 5 d. Ovariectomized females with no hormone replacement displayed context discrimination at 5 d, whereas those receiving 17ß-estradiol generalized their fear response to a neutral context. These results demonstrate that fear generalization for contextual cues occurs faster in female rats and is mediated, in part, by estrogens.
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A