Home-based child caregivers face unique stressors related to the nature of their work. One hundred and fifty-five home-based child care providers in Oregon, USA, participated in this cross-sectional correlational study. We investigated associations between indicators of caregiver stress and child care working conditions, the quality of caregiver practices, frequency of child behaviour challenges, and caregivers' tolerance for those behaviours. Levels of stress in this sample were moderate to low. Significant associations were found between greater caregiver stress with higher child-caregiver ratio, working in isolation, less frequently observed caregiver positive attention, more caregiver-reported child problem behaviours and lower tolerance for problem behaviours. A multiple regression analysis with these variables significantly contributed to 23% of the variance of caregiver stress. Number of hours worked, observed caregiver negative attention, and responsiveness to children were not associated with caregiver stress. Implications of these findings and the need for future studies are discussed.