This current study, investigated the relative effectiveness of Emotional Intelligence Training (EIT) and Locus of Control Training (LCT) on the psychological well-being of adolescent with visual impairment. The pretest-posttest control group experimental design with a 3x2x2 factorial matrix was used. The participants were 120 adolescents with visual impairment purposively selected from three integrated secondary schools in Ogbomosho, Ibadan and Owo in South-West Nigeria. Two valid and reliable instruments were used to assess levels of visual impairment and psychological well-being. Three research questions guided the study. Data were analyzed using Analysis of Covariance, while Duncan test was used for post hoc analysis. The result indicated that EIT and LCT were effective in fostering psychological well-being among the participants. However, EIT was superior in terms of outcomes. Also, type of visual impairment and gender did not mediate effectively the causal link between the treatments and criterion measure. Suggestions and recommendations were made based on the findings.