In their critique of differential response (DR), Hughes and colleagues raise a number of important issues that are central to broader efforts at the Administration on Children, Youth, and Families (ACYF) including the need for greater reliance on evidence-based practice in child welfare, more rigorous evaluation methodologies, and a robust set of measures and instruments to guide practice and evaluation. ACYF is pursuing these goals with projects to increase focus on child well-being, improve associated measures, promote the use of evidence-based programs, and expand the evidence base. We believe that DR is a promising practice and expect forthcoming results from an ACYF-sponsored multisite evaluation of DR to significantly enhance the evidence base. Future efforts can build on these results by focusing on social and emotional well-being in addition to safety and permanency, using demonstrated assessments to monitor outcomes, and offering families in both alternative and investigative pathways evidence-based services.