This study uses social capital to assess the effects of social support on acculturation-related stress among recently immigrated Hispanics in South Florida before and after immigration. At baseline ("N" = 527), first 12 months in the United States, acculturative stress was negatively related to support from friends ("p" < 0.044) and positively related to support from parents ("p" < 0.023). At first follow-up ("n" = 415), 24 months in the United States, emotional/informational support was negatively associated with acculturation-related stress ("p" < 0.028). In the second follow-up ("n" = 478), 36 months in the United States, support from children was negatively associated with acculturation-related stress ("p" < 0.016). Limited English proficiency was found to be negatively associated with acculturation stress at all three points ("p" < 0.001, "p" < 0.025, and "p" < 0.001, respectively). Implications of this study can be used in the design of culturally appropriate and family-oriented interventions for recent immigrants to ease the acculturation process.