ERIC Number: EJ1019177
Record Type: Journal
Publication Date: 2013-Sep
Abstractor: As Provided
White Matter and Development in Children with an Autism Spectrum Disorder
Mak-Fan, Kathleen M.; Morris, Drew; Vidal, Julie; Anagnostou, Evdokia; Roberts, Wendy; Taylor, Margot J.
Autism: The International Journal of Research and Practice, v17 n5 p541-557 Sep 2013
Recent research suggests that brain development follows an abnormal trajectory in children with autism spectrum disorders (ASD). The current study examined changes in diffusivity with age within defined white matter tracts in a group of typically developing children and a group of children with an ASD, aged 6 to 14 years. Age by group interactions were observed for frontal, long distant, interhemispheric and posterior tracts, for longitudinal, radial and mean diffusivity, but not for fractional anisotropy. In all cases, these measures of diffusivity decreased with age in the typically developing group, but showed little or no change in the ASD group. This supports the hypothesis of an abnormal developmental trajectory of white matter in this population, which could have profound effects on the development of neural connectivity and contribute to atypical cognitive development in children with ASD.
Descriptors: Brain, Children, Autism, Pervasive Developmental Disorders, Age Differences, Child Development, Early Adolescents, Comparative Analysis, Correlation, Brain Hemisphere Functions, Neurological Impairments, Cognitive Development
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A
Identifiers - Location: Canada (Toronto)
Identifiers - Assessments and Surveys: Autism Diagnostic Observation Schedule
Grant or Contract Numbers: N/A