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ERIC Number: EJ1019143
Record Type: Journal
Publication Date: 2013
Pages: 12
Abstractor: As Provided
ISSN: ISSN-0211-2159
A Comparison of the Effectiveness of Three Drug Regimens on Cognitive Performance of Patients with Parkinson's disease
Emsaki, Golit; Asgari, Karim; Molavi, Hossein; Chitsaz, Ahmad
Psicologica: International Journal of Methodology and Experimental Psychology, v34 n2 p273-284 2013
In the present study, the effectiveness of 3 drug regimen on cognitive performance of PD patients was compared. 12 patients who had been using pramipexole, levodopa and amantadine for at least 1 month entered the study and compared with those 12 who had been using trihexiphenidyle, levodopa and amantadine. There was also a control group including 11 patients who had been using only levodopa and amantadine. All 3 groups were asked to answer Montreal Cognitive Assessment in pretest phase. Then patients in experimental groups were asked not to use pramipexole or trihexiphenidyle for 72 hours and then all 3 groups were asked to answer the same questionnaire in post test phase. The results showed that patients who have used pramipexole had better performance in executive functions in post test. The findings suggest that pramipexole in combination with levodopa and amantadine may worsen the executive function in Parkinson's disease; however, there is almost neither adverse nor beneficial effect of trihexiphenidyl in such a combination on cognition in PD patients.
University of Valencia. Dept. Metodologia, Facultad de Psicologia, Avda. Blasco Ibanez 21, 46010 Valencia, Spain. Tel: +34-96-386-4100; Web site:
Publication Type: Reports - Research; Journal Articles
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Assessments and Surveys: Beck Anxiety Inventory; Beck Depression Inventory
Grant or Contract Numbers: N/A