In this chapter, we describe the evolution of an intermediary organization, the Institute for Learning (IFL) at the University of Pittsburgh, devoted to improving teaching and learning in some of America's largest and most challenged school districts. Over the nearly 20 years of IFL's life, we have learned that design-based researchers have to move beyond classrooms and focus on entire school systems if they hope their innovations will scale and sustain. Specifically, we believe the best way to develop capacity for sustaining innovation is through the careful design of practices intended to provide an ongoing forum for mutual engagement among actors from various levels of the education system. These practices, we have found, provide a productive way for actors from different levels of the system to understand and support the local activity of other levels.