First-year experience courses, although common on university campuses, are conducted in a variety of formats. This article outlines strategies and activities used at a large urban commuter campus in a first-year experience sequence run by the Department of Mathematics and Statistics for the College of Science. The course, designed for freshmen science and mathematics majors, is conducted across two quarters. The first quarter focuses on the theory and practice of science, whereas the focus for the second quarter is discipline specific--in this case, mathematics. Both courses contain some college-life content, but the true emphasis of this first-year experience sequence is on science and mathematics. Although not a complete course outline, the authors share resources, course-development strategies, and anecdotal evidence of successful course components.