The purpose of study was to understand the correlation between the needs of the learning effect on instructional website for the vocational high school students. Our research applied the statistic methods of product-moment correlation, stepwise regression, and structural equation method to analyze the questionnaire with the sample size of 377 participants. The empirical results showed that the explanatory factors representing the needs for instructional website can be orderly ranked as: the content and structure of teaching materials, the interactive design, the establishment of system configuration, the layout design, and the interface design. The explanatory factors representing the learning effect of the instructional website can be orderly ranked as the learning environment and equipment, the system learning, the courses interactive, the teaching effect. In addition, the needs for instructional website were positively correlated to the learning effect. The interaction design was intermediately correlated to establishment of system configuration.