This article explores conceptual and methodological similarities between Rational Emotive Behavior Therapy (REBT) and Tibetan Buddhism (TB). The authors examine some of the values and concepts they share. They compare the two systems on a number of issues: philosophical underpinnings, concepts of what causes human psychopathology, techniques to bring about change, outcome expectancies and goals. The purpose of this exploration is to increase awareness of the need for Western psychotherapists to develop a comprehensive science of the mind to help humans overcome difficulties and to live more fulfilling lives.