ERIC Number: EJ1016891
Record Type: Journal
Publication Date: 2013-Jun
Abstractor: As Provided
Reference Count: 11
Using Molecular Models To Show Steric Clash in Peptides: An Illustration of Two Disallowed Regions in the Ramachandran Diagram
Halkides, Christopher J.
Journal of Chemical Education, v90 n6 p760-762 Jun 2013
In this activity, students manipulate three-dimensional molecular models of the Ala-Ala-Ala tripeptide, where Ala is alanine. They rotate bonds to show that the pairs of dihedral angles phi = 0 degrees, psi = 180 degrees, and phi = 0 degrees, psi = 0 degrees lead to unfavorable interactions among the main chain atoms of the tripeptide. This activity allows the student to visualize in three dimensions why these two pairs of dihedral angles fall within the disallowed region of the Ramachandran diagram, a fundamental tool in the understanding and teaching of protein structure. The advanced activity introduces biochemistry students to unfavorable interactions of the beta carbon of the side chain.
Descriptors: Molecular Structure, Models, Science Instruction, College Science, Undergraduate Study, Hands on Science, Visualization, Biochemistry
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: firstname.lastname@example.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education; Postsecondary Education
Authoring Institution: N/A