ERIC Number: EJ1016841
Record Type: Journal
Publication Date: 2013-Dec
Abstractor: As Provided
Reference Count: 70
Pattern Recognition Receptors in Innate Immunity, Host Defense, and Immunopathology
Suresh, Rahul; Mosser, David M.
Advances in Physiology Education, v37 n4 p284-291 Dec 2013
Infection by pathogenic microbes initiates a set of complex interactions between the pathogen and the host mediated by pattern recognition receptors. Innate immune responses play direct roles in host defense during the early stages of infection, and they also exert a profound influence on the generation of the adaptive immune responses that ensue. An improved understanding of the pattern recognition receptors that mediate innate responses and their downstream effects after receptor ligation has the potential to lead to new ways to improve vaccines and prevent autoimmunity. This review focuses on the control of innate immune activation and the role that innate immune receptors play in helping to maintain tissue homeostasis.
Descriptors: Pathology, Immunization Programs, Pattern Recognition, Prevention, Disease Control, Role, Physiology, Genetics, Science Instruction, Molecular Structure, Cytology
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Publication Type: Journal Articles; Reports - Evaluative; Information Analyses
Education Level: N/A
Authoring Institution: N/A