This study investigated the effects of a peer-delivered system of least prompts intervention and adapted grade-level science read-alouds on correct listening comprehension responses for participants with moderate intellectual disability. The intervention package included prompts in which selected text was read again. Participants directed the amount of assistance they received from peer tutors by asking for help when needed and self-monitored their independent correct responses. Text was adapted from fourth grade science curricula currently being used by the general education fourth grade class. A question template was used to create factual recall and inferential questions and a multiple probe design across participants was used to determine the functional relationship between the system of least prompts intervention and listening comprehension. Outcomes indicated that the intervention was effective for teaching listening comprehension for all participants, but intervention effects did not generalize to untrained lessons. The study's contributions to research, limitations, need for future research, and implications for practice are discussed.