This article presents an overview of adult suicide in the United States and Alabama. This includes the latest available information on the prevalence of suicide in the US and Alabama, demographic characteristics of suicide victims, trends in suicide, and known reasons behind adult suicide. With respect to adult suicide in Alabama, it focuses on economic issues and the recent occurrences of natural disasters. Also provided are risk factors and early, acute warning signs for potentially suicidal adults as well as selected strategies for preventing individual suicides.