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ERIC Number: EJ1015871
Record Type: Journal
Publication Date: 2013-Nov
Pages: 21
Abstractor: As Provided
ISSN: ISSN-1944-7515
Physiological Arousal in Autism and Fragile X Syndrome: Group Comparisons and Links with Pragmatic Language
Klusek, Jessica; Martin, Gary E.; Losh, Molly
American Journal on Intellectual and Developmental Disabilities, v118 n6 p475-495 Nov 2013
This study tested the hypothesis that pragmatic (i.e., social) language impairment is linked to arousal dysregulation in autism spectrum disorder (ASD) and fragile X syndrome (FXS). Forty boys with ASD, 39 with FXS, and 27 with typical development (TD), aged 4-15 years, participated. Boys with FXS were hyperaroused compared to boys with TD but did not differ from boys with ASD. Dampened vagal tone predicted pragmatic impairment in ASD, and associations emerged between cardiac activity and receptive/expressive vocabulary across groups. Findings support autonomic dysfunction as a mechanism underlying pragmatic impairment in ASD and suggest that biophysiological profiles are shared in ASD and FXS, which has implications for understanding the role of "fragile X mental retardation-1" ("FMR1," the FXS gene) in the pathophysiology of ASD.
American Association on Intellectual and Developmental Disabilities. P.O. Box 1897, Lawrence, KS 66044-1897. Tel: 785-843-1235; Fax: 785-843-1274; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A