Objective: To systematically review literature focused on the health information seeking practices of sexual minority youth (SMY), those youth who identify as lesbian, gay or bisexual. The aims of this systematic literature review were to determine the health information seeking practices of SMY by: (1) identifying their commonly cited sources of health information; (2) examining barriers associated with accessing health information; and (3) identifying study methodologies used in research with SMY. Method: A systematic review of the health information seeking practices of SMY was conducted. Empirical studies published between 1990 and 2010 on the health information seeking and health communication practices of SMY were found using medical/health and sociology databases. Results: A total of 398 citations were retrieved from four databases using specific search terms. Nineteen articles met the inclusion criteria of: written in English; peer reviewed; original empirical study; and referenced search terms in title, abstract or keywords. Conclusion: Findings show inaccurate and limited health information targeted specifically toward SMY. Without culturally specific and accurate health information, it will be difficult for health educators and healthcare professionals to address the health concerns faced by this population. (Contains 1 table and 1 figure.)