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ERIC Number: EJ1014854
Record Type: Journal
Publication Date: 2013-Aug
Pages: 9
Abstractor: As Provided
ISSN: ISSN-0021-9630
A Novel Differential Susceptibility Gene: "CHRNA4" and Moderation of the Effect of Maltreatment on Child Personality
Grazioplene, Rachael G.; DeYoung, Colin G.; Rogosch, Fred A.; Cicchetti, Dante
Journal of Child Psychology and Psychiatry, v54 n8 p872-880 Aug 2013
Background: The differential susceptibility hypothesis states that some genetic variants that confer risk in adverse environments are beneficial in normal or nurturing environments. The cholinergic system is promising as a source of susceptibility genes because of its involvement in learning and neural plasticity. The cholinergic receptor gene "CHRNA4" has been linked to characteristics related to the personality traits Neuroticism and Openness/Intellect. Methods: The effects of interaction between "CHRNA4" genotype and maltreatment status on child personality were examined in a well matched sample of 339 maltreated and 275 non-maltreated children (aged 8-13 years). Results: Variation in "CHRNA4" interacted with childhood maltreatment to predict personality in a manner indicating differential susceptibility. The interaction of "CHRNA4" and maltreatment status predicted Neuroticism and Openness/Intellect. Maltreated children with the rs1044396 T/T genotype scored highest on Neuroticism and showed no effect of genotype on Openness/Intellect. Non-maltreated children with this genotype scored lowest on Neuroticism and highest on Openness/Intellect. Conclusion: Variation in "CHRNA4" appears to contribute to personality by affecting degree of developmental sensitivity to both normal and adverse environments. (Contains 3 tables and 1 figure.)
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Location: New York
Identifiers - Assessments and Surveys: California Child Q Set
Grant or Contract Numbers: N/A