First-generation undergraduate students face challenging cross-socioeconomic cultural transitions into college life. The authors compared first- and non-first-generation undergraduate students' social support, posttraumatic stress, depression symptoms, and life satisfaction. First-generation participants reported less social support from family and friends, more single-event traumatic stress, less life satisfaction, and marginally more depression symptomatology than non-first-generation participants, but significant generation-gender interactions showed first-generation women doing worse and first-generation men doing better than others. (Contains 3 tables.)